Lec 27 MIT 7.012 Introduction to Biology, Fall 2004
Good morning. Thank you. So, I want to continue today on the theme of neurobiology. Last time we spoke about the action potential mechanism. Today I'd like to go from action potential to the synapse. But let me briefly remind us what we say. So, I'm going to give section zero a recap here. The relevant things that we said last time was there's a membrane potential which at rest is about minus 70 millivolts as the membrane potential, and that's what we work with. That membrane potential is set up by concentration gradients. More calcium, more potassium on the inside. More sodium on the outside. More calcium on the outside. And I'm also going to mention chloride, there's more chloride on the outside at 116 millimolar, four millimolar on the outside. These concentration gradients are set up by various different pumps. They're there all the time. Then we have this resting channel. So, here we have trans...