Lecture 12 Pharmacogenomics
JEFFREY MARK DRAZEN: So this is how I view pharmacogenomics. It's the use of genetic information to determine who will respond favorably or unfavorably. And I think, actually, unfavorably may be a better phenotype to a given type of treatment. And the reason I say that is that, especially the condition that I study, asthma, there are a lot of folks that have a placebo effect from treatment. And so if I'm studying a drug and I give everybody a placebo-- that's my trial. I compare placebo A to the pink placebo, to the yellow placebo. And I know this is just a sugar pill and shouldn't have any biological impact on asthma. But I know that 25% of people are going to get better from this. And if I'm stratifying my outcome by genotypes, you'll see that I could be misled. But if I'm looking for a phenotype which is less likely to be contaminated by a placebo effect-- for example, people who get worse with treatment-- then I'm looking at the natural...