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Showing posts with the label RAMONI:

Lecture 9 Machine-learning Approach

MARCO RAMONI: Today I'm going to talk to you about the-- about basic genetics, what geneticists do, and how genetics is moving into the genomic area by increasing the size, the scope, and the quality of genetic studies. We'll do-- [DOOR CREAKING] You can close the door. So the origin of all of this is-- I will put myself at the particular time point, and the origin of all of this is the publication of the Human-- of the results of the Human Genome Project, a first draft of the human genome. And when they announced the publication of the human genome, the first item on the future agenda was a SNP map, and they said, this SNP map promises to revolutionize both mapping diseases and tracking human history. And I will try to show you how you do both using SNPs, and if you don't know what SNPs are, hold onto your breath. You will know it in a second. [DOOR CREAKING] Please. The SNPs, I will tell you in a second in more-- in detail. SNPs are things called single nucl...

Lecture 10 Association with Markers

MARCO RAMONI: What I'm going to talk about after this little introduction about microarrays is how to analyze this BLAST data. And the principle that I try to present to you is that there is no such a thing as putting your data into a freaking machine and expecting to get an answer. The type of analysis you make is always related to the question you're asking. This has to be a completely stupid point. But the tragedy of a lot of this field is that it's not. And a lot of people usually try to answer the same question using different methods and different questions using the same methods, which is even more disturbing. What I'm trying to tell you today is what kind of problems you can tackle with this kind of data and what kind of analysis you need to answer every different question. It's going to be very basic. I will introduce some kind of advanced notions at the end. But most of the rest is very basic and is what is routinely done by people in papers,...