Lecture 13 Case Hx Complex Traits
SCOTT WEISS: So this is an outline of what I'm going to talk about, and we're going to begin by of getting at this question of why complex trait human genetics is so difficult. And then go through each of the steps that you would do if you were actually doing this work. The first question you would get asked on an NIH grant application is your phenotype heritable? And so some evidence of heritability, or doing a study to determine heritability, is often the first step in a genetic study. And so we're going to talk a little bit about heritability and how you define that, and then identifying disease phenotypes-- so that's a critical issue-- the difference between a subphenotype and an intermediate phenotype, how you want to look at those things, then developing your study design. And the paper that I just was telling you about, this paper that's coming out in science, these people looked at two relative genetic isolates-- the population of Finland and t...